herpes simplex type i infection and atopy association in turkish children with asthma and allergic rhinitis
نویسندگان
چکیده
this study investigated the association between hsv-1 infection and atopy by comparing seropositivity to hsv-1 in atopic children with asthma and allergic rhinitis and in non-atopic children. totally 249 children randomly selected from the university outpatient pediatric clinics were prospectively enrolled in the study between september 1 and november 30, 2007. serum samples were examined using the virus neutralization test (vnt) for hsv-1 immunoglobulin g(igg) seropositivity. skin prick tests (spts) were performed to determine atopic status. the results showed that hsv-1 igg seropositivity was significantly higher in atopic children (56.8%) with asthma and allergic rhinitis than in the age-matched non-atopic children group (30.4%) (p these results support a possible relationship between the atopic status of children with asthma and allergic rhinitis and hsv-1 infection.
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association between ptpn22/ ctla-4 gene polymorphism and allergic rhinitis with asthma in children
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allergic rhinitis (ar) is an ige-mediated upper airway disease, and its impact on asthma has been widely recognized. protein tyrosine phosphatase non-receptor 22 (ptpn22) gene and the cytotoxic t-lymphocyte–associated antigen 4 (ctla-4) gene polymorphisms have been reported to be associated with several immune-related diseases. here we investigated the reffect of these two genes’ polymorphisms ...
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عنوان ژورنال:
iranian journal of allergy, asthma and immunologyجلد ۸، شماره ۳، صفحات ۱۴۹-۱۵۴
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